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63676-25-5

63676-25-5 structure
63676-25-5 structure
  • Name: LY 117018
  • Chemical Name: Phenethipylone
  • CAS Number: 63676-25-5
  • Molecular Formula: C27H25NO4S
  • Molecular Weight: 459.55700
  • Catalog: Research Areas Cancer
  • Create Date: 2016-06-24 22:40:29
  • Modify Date: 2024-01-24 12:17:23
  • LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines[1][2].
Name Phenethipylone
Synonyms Methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone
6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone
Description LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines[1][2].
Related Catalog
Target

Estrogen receptor

In Vitro LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation[1]. LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC50 of 1 μM[2]. LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway[3]. Cell Proliferation Assay[2] Cell Line: MCF-7 cells Concentration: 1 μM Incubation Time: 96 hours Result: Inhibited MCF-7 cells proliferation with an IC50 of 1 μM.
References

[1]. Dinda S, et al. Effects of LY117018 (a SERM analog of raloxifene) on tumor suppressor proteins and proliferation of breast cancer cells.Horm Mol Biol Clin Investig. 2010 Aug 1;2(1):211-7.

[2]. Baumann KH, et al. Effects of celecoxib and ly117018 combination on human breast cancer cells in vitro.Breast Cancer (Auckl). 2009 Apr 7;3:23-34.

[3]. Yu J, et al.Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.Eur J Pharmacol. 2008 Jul 28;589(1-3):32-6.
Density 1.314g/cm3
Boiling Point 721.5ºC at 760 mmHg
Molecular Formula C27H25NO4S
Molecular Weight 459.55700
Flash Point 390.2ºC
Exact Mass 459.15000
PSA 98.24000
LogP 5.62300
Index of Refraction 1.679

Chemsrc provides CAS#:63676-25-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 63676-25-5 | Chemsrc address: https://www.chemsrc.com/en/baike/336535.html

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