60-91-3

60-91-3 structure

60-91-3 structure

Name: diethazine
Chemical Name: N,N-diethyl-2-phenothiazin-10-ylethanamine
CAS Number: 60-91-3
Molecular Formula: C₁₈H₂₂N₂S
Molecular Weight: 298.44600
Catalog: API Nervous system medication Anti-shock palsy
Create Date: 2018-04-06 08:00:00
Modify Date: 2024-01-14 17:30:32

Name	N,N-diethyl-2-phenothiazin-10-ylethanamine
Synonyms	Fourneau 2987 Diethazine [INN:BAN] Lodibon Diethazine Dolisina Casantin [German] Diaethazinum diethyl-(2-phenothiazin-10-yl-ethyl)-amine N,N-diethyl-10H-phenothiazine-10-ethanamine Diaethyl-(2-phenothiazin-10-yl-aethyl)-amin Eazamine Diethazinum [INN-Latin] Dietazina [INN-Spanish] 10-[2-(diethylamino)ethyl]phenothiazine

Density	1.115g/cm3
Boiling Point	422.2ºC at 760 mmHg
Molecular Formula	C₁₈H₂₂N₂S
Molecular Weight	298.44600
Flash Point	209.1ºC
Exact Mass	298.15000
PSA	31.78000
LogP	4.69610
Index of Refraction	1.608

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO4200000

CHEMICAL NAME :: Phenothiazine, 10-(2-(diethylamino)ethyl)-

CAS REGISTRY NUMBER :: 60-91-3

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H22-N2-S

MOLECULAR WEIGHT :: 298.48

WISWESSER LINE NOTATION :: T C666 BN ISJ B2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,371,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - rigidity (including catalepsy)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,255,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,171,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HPPAAL Helvetica Physiologia et Pharmacologica Acta. (Basel, Switzerland) V.1-26, 1943-68. Discontinued. Volume(issue)/page/year: 16,277,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

HS Code	2934300000

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%