DC Chemicals Limited
China
Product Name: PIH(Pyridoxal isonicotinoyl hydrazine)
Price: $250.0/100mg $450.0/250mg $900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: PIH(Pyridoxal isonicotinoyl hydrazine)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pyridoxal isonicotinoyl hydrazone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

737-86-0

737-86-0 structure

737-86-0 structure

Name: Pyridoxal isonicotinoyl hydrazone
Chemical Name: pih
CAS Number: 737-86-0
Molecular Formula: C₁₄H₁₄N₄O₃
Molecular Weight: 286.29
Catalog: Research Areas Cancer
Create Date: 2017-11-08 02:00:32
Modify Date: 2024-01-06 21:09:53
Pyridoxal isonicotinoyl hydrazone (PIH) is a lipophilic, tridentate Fe-chelating agent that shows high Fe chelation efficacy[1].

Name	pih
Synonyms	pyridoxal N-(isonicotinoyl)hydrazone Pyridoxal hydrochloride 1GR pyridoxal HCl PL HCL PyridoxalHydrochlorideMin. Pyridoxal,Hydrochlorid 3-hydroxy-5-hydroxymethyl-2-methyl-pyridine-4-carbaldehyde,hydrochloride Pyridoxal-[2H3] hydrochloride Pyridoxal hydrochloride 5GR Pyridoxal hydrochlor 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde,hydrochloride pyridoxal isonicotinoyl hydrazone Pyridoxalhydrochloride

Description	Pyridoxal isonicotinoyl hydrazone (PIH) is a lipophilic, tridentate Fe-chelating agent that shows high Fe chelation efficacy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Hermes-Lima M, et al. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate. Biochim Biophys Acta. 2000 Oct 18;1523(2-3):154-60. [2]. Landschulz W, et al. A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation. J Cell Biol. 1984 Feb;98(2):596-601.

Density	1.35g/cm3
Molecular Formula	C₁₄H₁₄N₄O₃
Molecular Weight	286.29
Exact Mass	286.10700
PSA	107.70000
LogP	1.13770
Index of Refraction	1.646
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5760000

CHEMICAL NAME :: 4-Pyridinecarboxylic acid, ((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl)me thylene) hydrazide

CAS REGISTRY NUMBER :: 737-86-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C14-H14-N4-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - fatty liver degeneration

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - fatty liver degeneration

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 72 gm/kg/90D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 14,395,1991