145414-76-2

145414-76-2 structure

Name: 6',7'-DIHYDROXYBERGAMOTTIN
Chemical Name: 6´,-7´-Dihydroxybergamottin
CAS Number: 145414-76-2
Molecular Formula: C₂₁H₂₂O₆
Molecular Weight: 370.396
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2018-08-02 09:09:00
Modify Date: 2024-01-07 11:08:40
6',7'-Dihydroxybergamottin (6′,7′-DHB) is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice[1].

Name	6´,-7´-Dihydroxybergamottin
Synonyms	7H-Furo[3,2-g][1]benzopyran-7-one, 5-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-2,3-dihydroxy- 6',7'-Dihydroxy Bergamottin 5-{[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy}-2,3-dihydroxy-7H-furo[3,2-g]chromen-7-one

Description	6',7'-Dihydroxybergamottin (6′,7′-DHB) is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	CYP3A4
References	[1]. D J Edwards, et al. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther. 1999 Mar;65(3):237-44.

Density	1.3±0.1 g/cm3
Boiling Point	611.3±55.0 °C at 760 mmHg
Melting Point	112-113 °C
Molecular Formula	C₂₁H₂₂O₆
Molecular Weight	370.396
Flash Point	323.5±31.5 °C
Exact Mass	370.141632
PSA	93.04000
LogP	5.57
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.633

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

206978-14-5

~72%

145414-76-2

Literature: BIOAVAILABILITY SYSTEMS, LLC Patent: WO2004/37827 A1, 2004 ; Location in patent: Page 30 ;

7380-40-7

145414-76-2

Literature: Ohta, Tomihisa; Maruyama, Takuro; Nagahashi, Minoru; Miyamoto, Yasuyo; Hosoi, Shinzo; Kiuchi, Fumiyuki; Yamazoe, Yasushi; Tsukamoto, Sachiko Tetrahedron, 2002 , vol. 58, # 33 p. 6631 - 6635

6138-90-5

145414-76-2

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

486-60-2

145414-76-2

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

484-20-8

145414-76-2

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

Precursor 5
206978-14-5 7380-40-7 6138-90-5 486-60-2
484-20-8
DownStream 0

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35118-14-0	883647-79-8