6',7'-DIHYDROXYBERGAMOTTIN
6',7'-DIHYDROXYBERGAMOTTIN structure
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Common Name | 6',7'-DIHYDROXYBERGAMOTTIN | ||
|---|---|---|---|---|
| CAS Number | 145414-76-2 | Molecular Weight | 370.396 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 611.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H22O6 | Melting Point | 112-113 °C | |
| MSDS | Chinese USA | Flash Point | 323.5±31.5 °C | |
Use of 6',7'-DIHYDROXYBERGAMOTTIN6',7'-Dihydroxybergamottin (6′,7′-DHB) is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice[1]. |
| Name | 6´,-7´-Dihydroxybergamottin |
|---|---|
| Synonym | More Synonyms |
| Description | 6',7'-Dihydroxybergamottin (6′,7′-DHB) is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice[1]. |
|---|---|
| Related Catalog | |
| Target |
CYP3A4 |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 611.3±55.0 °C at 760 mmHg |
| Melting Point | 112-113 °C |
| Molecular Formula | C21H22O6 |
| Molecular Weight | 370.396 |
| Flash Point | 323.5±31.5 °C |
| Exact Mass | 370.141632 |
| PSA | 93.04000 |
| LogP | 5.57 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.633 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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~72%
6',7'-DIHYDROXY... CAS#:145414-76-2 |
| Literature: BIOAVAILABILITY SYSTEMS, LLC Patent: WO2004/37827 A1, 2004 ; Location in patent: Page 30 ; |
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6',7'-DIHYDROXY... CAS#:145414-76-2 |
| Literature: Ohta, Tomihisa; Maruyama, Takuro; Nagahashi, Minoru; Miyamoto, Yasuyo; Hosoi, Shinzo; Kiuchi, Fumiyuki; Yamazoe, Yasushi; Tsukamoto, Sachiko Tetrahedron, 2002 , vol. 58, # 33 p. 6631 - 6635 |
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6',7'-DIHYDROXY... CAS#:145414-76-2 |
| Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610 |
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6',7'-DIHYDROXY... CAS#:145414-76-2 |
| Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610 |
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~%
6',7'-DIHYDROXY... CAS#:145414-76-2 |
| Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610 |
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Grapefruit juice, lyophilized grapefruit juice, and powdered whole grapefruit inhibit cytochrome P450-mediated triazolam hydroxylation by beagle dog liver microsomes.
J. Vet. Pharmacol. Ther. 33(2) , 189-95, (2010) Coadministration of grapefruit juice (GFJ) has been proposed to enhance the systemic availability and decrease the required dose of drugs such as cyclosporine that are extensively metabolized in the i... |
| 7H-Furo[3,2-g][1]benzopyran-7-one, 5-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-2,3-dihydroxy- |
| 6',7'-Dihydroxy Bergamottin |
| 5-{[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy}-2,3-dihydroxy-7H-furo[3,2-g]chromen-7-one |