73032-94-7

73032-94-7 structure

Name: Somatostatin-28 trifluoroacetate salt
Chemical Name: Prosomatostatin
CAS Number: 73032-94-7
Molecular Formula: C₁₃₇H₂₀₇N₄₁O₃₉S₃
Molecular Weight: 3148.56000
Catalog: Biochemical Peptide
Create Date: 2018-02-25 08:00:00
Modify Date: 2024-01-02 21:14:33
Somatostatin-28 (sheep) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

Name	Prosomatostatin
Synonyms	Somatostatin-28 Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys Somatostatin 28,Cyclic MFCD00076772 Somatostatin-28 (sheep) 28

Description	Somatostatin-28 (sheep) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Metabolic Disease
Target	SSTR5
In Vitro	Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM[1]。
In Vivo	Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌[2]。 Animal Model: Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2] Dosage: 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose; Administration: Intravenous injection via a jugular catheter; Result: Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
References	[1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12. [2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3