29451-71-6

29451-71-6 structure

Name: Ranatensin
Chemical Name: ranatensin
CAS Number: 29451-71-6
Molecular Formula: C₆₁H₈₄N₁₆O₁₃S
Molecular Weight: 1281.48000
Catalog: Biochemical Peptide
Create Date: 2018-08-03 18:05:32
Modify Date: 2024-01-05 00:52:28
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)[1][2].

Name	ranatensin
Synonyms	5-Oxo-L-Pro-L-Val-L-Pro-L-Glu(NH2)-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2 GLP-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 pGlu-Val-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 PYROGLU-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 PGLU-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 PYR-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2

Description	Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor
In Vitro	Ranatensin (0.3 nM; 30 min) 能够刺激多种胰促分泌物诱导淀粉酶释放[1]。
In Vivo	Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 会增加狗和兔子的血压，表明其具有直接的外周血管收缩作用[2]。 Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 也能降低猴子的血压，与 Eledoisin (HY-P0006) 一样有效。它对血管平滑肌有直接的外周作用[2]。 Ranatesin (10-50 μg/mL, 0.005-0.1 mL; 静脉注射; 单剂量) 根据大鼠血压的基础水平具有可变的作用，在高水平时显示出降压效果，在低水平时升高血压，产生这一变化的可能原因是外周交感神经末梢释放去甲肾上腺素[2]。
References	[1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3. [2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3