76150-91-9
76150-91-9 structure
- Name: TCPOBOP
- Chemical Name: 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine
- CAS Number: 76150-91-9
- Molecular Formula: C16H8Cl4N2O2
- Molecular Weight: 402.05900
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2016-11-11 23:34:42
- Modify Date: 2024-01-21 06:46:16
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TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
| Name | 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine |
|---|---|
| Synonyms |
2,2'-[1,4-phenylenebis(oxy)]bis(3,5-dichloropyridine)
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene tcpobop 1,4-BDPOB 2,2'-[benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine) |
| Description | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2]. |
|---|---|
| Related Catalog | |
| Target |
Bcl-2 |
| In Vivo | TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1]. Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1] Dosage: 3 mg/kg Administration: Oral; 1, 2, 5 days Result: Increased Liver weight to body weight. |
| References |
| Density | 1.518g/cm3 |
|---|---|
| Boiling Point | 444.8ºC at 760 mmHg |
| Molecular Formula | C16H8Cl4N2O2 |
| Molecular Weight | 402.05900 |
| Flash Point | 222.8ºC |
| Exact Mass | 399.93400 |
| PSA | 44.24000 |
| LogP | 6.67480 |
| Index of Refraction | 1.635 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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