852329-66-9

852329-66-9 structure

Name: Dutogliptin
Chemical Name: [(2R)-1-[2-[[(3R)-pyrrolidin-3-yl]amino]acetyl]pyrrolidin-2-yl]boronic acid
CAS Number: 852329-66-9
Molecular Formula: C₁₀H₂₀BN₃O₃
Molecular Weight: 241.09500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Dipeptidyl Peptidase
Create Date: 2017-03-05 19:01:45
Modify Date: 2024-01-08 12:37:09
Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.

Name	[(2R)-1-[2-[[(3R)-pyrrolidin-3-yl]amino]acetyl]pyrrolidin-2-yl]boronic acid
Synonyms	Dutogliptin UNII-38EAO245ZX

Description	Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	DPP4[1]
In Vivo	Dutogliptin is highly water soluble (>2000 mg/mL), has low cellular permeability, exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. The compound is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].
References	[1]. Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. [2]. Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.