187400-85-7

187400-85-7 structure

Name: ER 50891
Chemical Name: 4-[5-(8-Isopropyl-4-phenyl-2-quinolinyl)-1H-pyrrol-2-yl]benzoic a cid
CAS Number: 187400-85-7
Molecular Formula: C₂₉H₂₄N₂O₂
Molecular Weight: 432.51300
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2016-01-10 18:08:50
Modify Date: 2024-04-03 10:27:11
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis[1].

Name	4-[5-(8-Isopropyl-4-phenyl-2-quinolinyl)-1H-pyrrol-2-yl]benzoic a cid

Description	ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RARα[1]
References	[1]. Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817.