1327-43-1

Potential Acute HealthSlightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Effects
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Not available.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.

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Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention
if symptoms appear.
Serious IngestionNot available.

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Section 5. Fire and Explosion Data
Flammability of the Product Non-flammable.
Auto-Ignition Temperature Not applicable.
Flash PointsNot applicable.
Not applicable.
Flammable Limits
Not available.
Products of Combustion
Fire Hazards in Presence of Not applicable.
Various Substances
Explosion Hazards inRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Presence of Various
Substances
Fire Fighting MediaNot applicable.
and Instructions
Not available.
Special Remarks on
Fire Hazards
Special Remarks on Explosion Not available.
Hazards
Magnesium aluminum silicate

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Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.

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Section 7. Handling and Storage
Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or
Precautions
the label.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.

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Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels
below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure LimitsNot available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Powder or flakes solid. Granular soli)OdorOdorless.
Not available.
Taste
Not available.
Molecular Weight
ColorWhite. Off-white.
pH (1% soln/water)Not applicable.
Boiling PointNot available.
Melting PointNot available.
Not available.
Critical Temperature
Specific Gravity2.6 (Water = 1)
Not applicable.
Vapor Pressure
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Water/Oil Dist. Coeff.Not available.
Not available.
Ionicity (in Water)
Dispersion PropertiesNot available.
Insoluble in cold water.
Solubility
Magnesium aluminum silicate

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Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Incompatible materials
Conditions of Instability
Incompatibility with various Reactive with oxidizing agents.
substances
Non-corrosive in presence of glass.
Corrosivity
Special Remarks onAvoid powerful oxidizing agents such as fluorine, chlorine trifluoride, manganese triocide adn oxygen
Reactivitydifluoride.
Special Remarks onNot available.
Corrosivity
Will not occur.
Polymerization

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Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsAcute oral toxicity (LD50): 16000 mg/kg [Rat].
Chronic Effects on Humans Not available.
Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onNot available.
Chronic Effects on Humans
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May respiratory tract irritation.
Ingestion: Low hazard. Low toxicity.

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Section 12. Ecological Information
Not available.
Ecotoxicity
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation
products may arise.
Toxicity of the ProductsNot available.
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation

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Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.
Magnesium aluminum silicate

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Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
IdentificationNot applicable.
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Magnesium aluminum silicate for CAS no. 1327-43-1; Smectite-group minerals for
Federal and State
CAS no. 12199-37-0
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has
found to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsFor CAS no. 1327-43-1:
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
No. 215-478-8).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Listed on National Inventory (KECI).
Philippines: Listed on National Inventory (PICCS).
Australia: Listed on AICS.
For CAS no. 12199-37-0:
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
No. 235-374-6).
Canada: Listed on Canadian Non-Domestic Substance List (NDSL).
China: Listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Listed on National Inventory (KECI).
Philippines: Listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
This product is not classifiedNot applicable.
DSCL (EEC)
according to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
0 Flammability
0 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
Magnesium aluminum silicate
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>16 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1164,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83046 No. of Facilities: 5916 (estimated) No. of Industries: 71 No. of Occupations: 100 No. of Employees: 110428 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83046 No. of Facilities: 7905 (estimated) No. of Industries: 90 No. of Occupations: 84 No. of Employees: 162965 (estimated) No. of Female Employees: 24342 (estimated)