1131-64-2

1131-64-2 structure

Name: 3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXIMIDAMIDE
Chemical Name: debrisoquin
CAS Number: 1131-64-2
Molecular Formula: C₁₀H₁₃N₃
Molecular Weight: 175.23
Catalog: Chemical reagent Organic reagent Barium salt
Create Date: 2018-09-18 14:32:50
Modify Date: 2024-01-08 16:54:51
Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1].

Name	debrisoquin
Synonyms	3,4-Dihydroisoquinoline-2(1H)-carboxiMidaMide EINECS 214-470-1 3,4-Dihydro-2(1H)-isochinolin-carboxamidin 3,4-dihydro-1H-isoquinoline-2-carboximidic acid amide 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide Debrisoquin Debrisochin 1,2,3,4-Tetrahydroisochinolin-N-carboxamidin 3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXAMIDINE Isocaramidine 3,4-Dihydro-2(1H)-isoquinolinecarbimidamide 3,4-dihydro-1H-isoquinoline-2-carboximidamide

Description	Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	Human Endogenous Metabolite
References	[1]. Amanda L. Peiffer, et.al.TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform.ACS Medicinal Chemistry Letters 2023 14 (6), 860-866.

HS Code	2933499090

25934-17-2

1131-64-2

91-21-4

1184-90-3

1131-64-2

Literature: McNeilab, Inc. Patent: US4656291 A1, 1987 ;

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%