64421-28-9

64421-28-9 structure

Name: Shanzhiside methylester
Chemical Name: shanzhiside methyl ester
CAS Number: 64421-28-9
Molecular Formula: C₁₇H₂₆O₁₁
Molecular Weight: 406.382
Catalog: Natural product Iridoid derivative
Create Date: 2018-09-23 09:45:54
Modify Date: 2024-01-02 22:40:55
Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].

Name	shanzhiside methyl ester
Synonyms	Methyl (1S,4aS,5R,7S,7aS)-1-(β-D-glucopyranosyloxy)-5,7-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate shanziside Me-ester shanziside methyl ester shanzhiside methy ester Shanzhiside methylester Shanzhiside methyl ester hanzhiside Methyl ester Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methyl-, methyl ester, (1S,4aS,5R,7S,7aS)- Shaniside methyl ester shanzhiside Me ester

Description	Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Target	IC50: GLP-1 receptor[1]
In Vivo	Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg[1].
References	[1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109.

Safety Phrases	22-24/25