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3778-29-8

3778-29-8 structure
3778-29-8 structure
  • Name: 6-Hydroxykynurenic acid
  • Chemical Name: 6-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid
  • CAS Number: 3778-29-8
  • Molecular Formula: C10H7NO4
  • Molecular Weight: 205.16700
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
  • Create Date: 2017-09-30 01:36:16
  • Modify Date: 2024-01-05 18:55:25
  • 6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].

Name 6-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid
Synonyms 6-Hydroxykynurenic acid
4,6-dihydroxy-2-carboxyquinoline
6-Hydroxykynureninsaeure
4,6-dihydroxy-quinoline-2-carboxylic acid
Quinaldic acid,4,6-dihydroxy
6-Hydroxykynurensaeure
6-Hydroxykynurenate
4,6-Dihydroxyquinaldic acid
4,6-Dihydroxy-chinolin-2-carbonsaeure
Description 6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].
Related Catalog
Target

IC50: 59 μM (NMDAR)[1]

References

[1]. Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77(4):1108-15.  

Density 1.569g/cm3
Boiling Point 455.6ºC at 760mmHg
Molecular Formula C10H7NO4
Molecular Weight 205.16700
Flash Point 229.4ºC
Exact Mass 205.03800
PSA 90.39000
LogP 0.93190
Index of Refraction 1.681
HS Code 2933499090
Precursor  0

DownStream  1

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%