6-Hydroxykynurenic acid

Modify Date: 2024-01-05 18:55:25

6-Hydroxykynurenic acid Structure
6-Hydroxykynurenic acid structure
Common Name 6-Hydroxykynurenic acid
CAS Number 3778-29-8 Molecular Weight 205.16700
Density 1.569g/cm3 Boiling Point 455.6ºC at 760mmHg
Molecular Formula C10H7NO4 Melting Point N/A
MSDS N/A Flash Point 229.4ºC

 Use of 6-Hydroxykynurenic acid


6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].

 Names

Name 6-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid
Synonym More Synonyms

 6-Hydroxykynurenic acid Biological Activity

Description 6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].
Related Catalog
Target

IC50: 59 μM (NMDAR)[1]

References

[1]. Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77(4):1108-15.  

 Chemical & Physical Properties

Density 1.569g/cm3
Boiling Point 455.6ºC at 760mmHg
Molecular Formula C10H7NO4
Molecular Weight 205.16700
Flash Point 229.4ºC
Exact Mass 205.03800
PSA 90.39000
LogP 0.93190
Index of Refraction 1.681

 Safety Information

HS Code 2933499090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

6-Hydroxykynurenic acid
4,6-dihydroxy-2-carboxyquinoline
6-Hydroxykynureninsaeure
4,6-dihydroxy-quinoline-2-carboxylic acid
Quinaldic acid,4,6-dihydroxy
6-Hydroxykynurensaeure
6-Hydroxykynurenate
4,6-Dihydroxyquinaldic acid
4,6-Dihydroxy-chinolin-2-carbonsaeure