854924-64-4

854924-64-4 structure

Name: ST 198
Chemical Name: N-[4-(3,4-dihydro-1H-isoquinolin-2-yl)butyl]-3-phenylprop-2-enamide
CAS Number: 854924-64-4
Molecular Formula: C₂₂H₂₆N₂O
Molecular Weight: 334.45
Create Date: 2017-11-07 18:15:21
Modify Date: 2024-01-12 15:24:54
ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease[1].

Name	N-[4-(3,4-dihydro-1H-isoquinolin-2-yl)butyl]-3-phenylprop-2-enamide

Description	ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vitro	ST 198 可以在对 D3R 具有选择性的剂量下阻断尼古丁诱导的 CPP 的表达[1]。
In Vivo	ST 198 (p.o.; 3, 30, 100 mg/kg) 抑制尼古丁 CPPs 的表达[1]。 Animal Model: Rats[1]. Dosage: 3, 30, 100 mg/kg Administration: p.o Result: Displayed nicotine-induced CPP.
References	[1]. Le Foll B, et al. Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects. Neuropsychopharmacology. 2005;30(4):720-730.