875770-34-6

875770-34-6 structure

Name: Biotin-PEG3-azide
Chemical Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]pentanamide
CAS Number: 875770-34-6
Molecular Formula: C₁₈H₃₂N₆O₅S
Molecular Weight: 444.549
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-10-06 09:43:15
Modify Date: 2024-01-03 08:08:04
Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name	5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]pentanamide
Synonyms	1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- Biotin-PEG3-Azide N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Description	Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	Biotin-C2-PEG3-azide is a biotin with the azide tag, it can be conjugated to antiviral inhibitors, for example, RYL-634, which shows excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika virus, chikungunya virus, enterovirus[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.J Med Chem. 2019 Apr 25;62(8):4056-4073.

Melting Point	110 °C
Molecular Formula	C₁₈H₃₂N₆O₅S
Molecular Weight	444.549
Exact Mass	444.215485
PSA	179.95000
LogP	-0.93

RIDADR	NONH for all modes of transport

35013-72-0

134179-38-7

~75%

875770-34-6

Literature: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; KOHN, Harold, L.; PARK, Ki Duk Patent: WO2010/14236 A2, 2010 ; Location in patent: Page/Page column 35 ;

134179-38-7

58-85-5

~89%

875770-34-6

Literature: Tantama, Mathew; Lin, Wan-Chen; Licht, Stuart Journal of the American Chemical Society, 2008 , vol. 130, # 47 p. 15766 - 15767

359860-27-8

~60%

875770-34-6

Literature: Yun, Wang; Shougang, Hu; Fast, Walter Journal of the American Chemical Society, 2009 , vol. 131, # 42 p. 15096 - 15097

134179-38-7

33755-53-2

~97%

875770-34-6

Literature: Tae, Hyun Seop; Hines, John; Schneekloth, Ashley R.; Crews, Craig M. Organic Letters, 2010 , vol. 12, # 19 p. 4308 - 4311

Precursor 5
35013-72-0 134179-38-7 58-85-5 359860-27-8
33755-53-2
DownStream 1
359860-27-8

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