111755-37-4

111755-37-4 structure

Name: Microcystin RR
Chemical Name: Microcystin RR from Microcystis aeruginosa
CAS Number: 111755-37-4
Molecular Formula: C₄₉H₇₅N₁₃O₁₂
Molecular Weight: 1038.200
Catalog: analytical chemistry Standard Volatile Organic Compounds (VOCs)
Create Date: 2018-05-11 08:00:00
Modify Date: 2024-01-08 13:17:50
Microcystin-RR (Cyanoviridin RR) is a potent and orally active protein phosphatase inhibitor. Microcystin-RR induces Apoptosis and ER stress in mice liver[1][2].

Name	Microcystin RR from Microcystis aeruginosa
Synonyms	MFCD00871765 (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-Bis(3-carbamimidamidopropyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid Microcystin RR 1,4,7,10,14,17,21-Heptaazacyclopentacosane-11,22-dicarboxylic acid, 8,15-bis[3-[(aminoiminomethyl)amino]propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-, (5R,8S,11R,12S,15S,18S,19S,22R)- (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-Bis(3-carbamimidamidopropyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid microcystin-RR

Description	Microcystin-RR (Cyanoviridin RR) is a potent and orally active protein phosphatase inhibitor. Microcystin-RR induces Apoptosis and ER stress in mice liver[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
In Vivo	Microcystin-RR (0、4..6、23、46、93、186 µg/mL；灌胃；每日一次，连续 7 天) 在小鼠肝脏中以剂量依赖性方式诱导细胞凋亡并增加 Bax、p53 的表达，降低 Bcl-2 的表达[2]。 Animal Model: 20-22 g, male ICR mice[2] Dosage: 0, 4..6, 23, 46, 93, 186 µg/mL Administration: Gavage; daily for 7 days Result: Induced obvious apoptosis in mice liver with the percentage of apoptotic cells were 10.46, 12.6, 12.7, 13.3, 28.5, and 37.5% for 0, 4..6, 23, 46, 93, 186 µg/mL, respectively; increased the expression of Bax,p53, decreased the expression of Bcl-2 in a dose-dependent manner in mice liver.
References	[1]. Matsushima R, et al. In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts. Biochem Biophys Res Commun. 1990 Sep 14;171(2):867-74. [2]. Huang P, et al. The apoptotic effect of oral administration of microcystin-RR on mice liver. Environ Toxicol. 2011 Oct;26(5):443-52.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H315-H317-H319-H330-H335
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;T+: Very toxic;F: Flammable;
Risk Phrases	R26/27/28
Safety Phrases	26-36/37/39-45-36/37-16
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3