4431-01-0

4431-01-0 structure

Name: Ligustilide
Chemical Name: Ligustilide
CAS Number: 4431-01-0
Molecular Formula: C₁₂H₁₄O₂
Molecular Weight: 190.238
Catalog: Biochemical Plant extracts
Create Date: 2018-05-31 08:00:00
Modify Date: 2024-01-02 18:23:15
Ligustilide is an effective constituent extracted from Angelica sinensis.IC50 value:Target:In vitro: To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide [1].In vivo:

Name	Ligustilide
Synonyms	3-BUTYLIDENE-4,5-DIHYDROPHTHALIDE 3-BUTYLIDEN-4,5-DIHYDRO-3H-ISOBENZOFURAN-1-ONE Ligustilide 3-Butyliden-1-oxo-1.3.4.5-tetrahydro-isobenzofuran Angelica Extract Powder LIGUSTILIDE,Z cis-ligustilide Ligustilide, (Z)- 1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)- Z-LIGUSTILIDE (3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one 3-butylidene-4,5-dihydro-3H-isobenzofuran-1-one

Description	Ligustilide is an effective constituent extracted from Angelica sinensis.IC50 value:Target:In vitro: To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide [1].In vivo:
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others Natural Products >> Others
References	[1]. Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50(2):162-8. [2]. Du H, et al. A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction. Se Pu. 2015 May;33(5):530-4.