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1937-37-7

1937-37-7 structure
1937-37-7 structure
  • Name: C.I. Direct Black 38
  • Chemical Name: Direct Black 38
  • CAS Number: 1937-37-7
  • Molecular Formula: C34H25N9Na2O7S2
  • Molecular Weight: 781.728
  • Catalog: Dyes and pigments dye Direct dye
  • Create Date: 2018-03-26 08:00:00
  • Modify Date: 2024-01-02 12:30:08
  • Direct Black 38 is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].

Name Direct Black 38
Synonyms AZO BLACK
Chlorazol Black E
MFCD00066363
Chlorazol Black E,certified
2,7-Naphthalenedisulfonic acid, 4-amino-3-[(E)-2-[4'-[(E)-2-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl]diazenyl]-5-hydroxy-6-[(E)-2-phenyldiazenyl]-, sodium salt (1:2)
C.I. Direct Black 38
Chlorazol Black
metablack
erieblackb
ERIE BLACK
2,7-naphthalenedisulfonic acid, 4-amino-3-[(E)-[4'-[(E)-(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-[(E)-phenylazo]-, disodium salt
black2embl
EINECS 217-710-3
Disodium 4-amino-3-[(E)-{4'-[(E)-(2,4-diaminophenyl)diazenyl]-4-biphenylyl}diazenyl]-5-hydroxy-6-[(E)-phenyldiazenyl]-2,7-naphthalenedisulfonate
black4embl
Description Direct Black 38 is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].
Related Catalog
References

[1]. Beije B. Induction of unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats exposed in vivo to the benzidine-derived azo dye, Direct Black 38. Mutat Res. 1987 Apr;187(4):227-34.

Density 1.61g/cm3
Melting Point 109-110°C
Molecular Formula C34H25N9Na2O7S2
Molecular Weight 781.728
Exact Mass 781.111389
PSA 303.61000
LogP 11.91860
Index of Refraction 1.768

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ6160000
CHEMICAL NAME :
2,7-Naphthalenedisulfonic acid, 4-amino-3-((4'-((2,4-diaminophenyl)azo)(1,1'-biphenyl )-4-yl) azo)-5-hydroxy-6-(phenylazo)-, disodium salt
CAS REGISTRY NUMBER :
1937-37-7
LAST UPDATED :
199801
DATA ITEMS CITED :
32
MOLECULAR FORMULA :
C34-H25-N9-O7-S2.2Na
MOLECULAR WEIGHT :
781.78
WISWESSER LINE NOTATION :
L66J BZ CNUNR DR DNUNR DR DNUNR BZ DZ&&& DSWO HSWO INUNR JQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 gm/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1262 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6825 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34 mg/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13286 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Body fluid assay
TEST SYSTEM :
Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION :
300 mg/kg
REFERENCE :
IAEHDW International Archives of Occupational and Environmental Health. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.35- 1975- Volume(issue)/page/year: 49,177,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,295,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,295,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1410 No. of Facilities: 704 (estimated) No. of Industries: 10 No. of Occupations: 27 No. of Employees: 16432 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1410 No. of Facilities: 298 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 11374 (estimated) No. of Female Employees: 5821 (estimated)
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H319-H350-H361d
Precautionary Statements P201-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R45;R63
Safety Phrases S53-S45
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS QJ6160000