88889-14-9

88889-14-9 structure

Name: Fosinopril sodium
Chemical Name: fosinopril sodium
CAS Number: 88889-14-9
Molecular Formula: C₃₀H₄₅NNaO₇P
Molecular Weight: 563.662
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-05-16 08:00:00
Modify Date: 2024-01-02 20:04:37
Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy [1-3].

Name	fosinopril sodium
Synonyms	Tensozide Dynacil Fosinopril sodium (4S)-4-Cyclohexyl-1-{[(R)-[(1R)-2-methyl-1-(propionyloxy)propoxy](4-phenylbutyl)phosphoryl]acetyl}-L-proline Fosinorm Staril sodium,(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate (4S)-4-cyclohexyl-1-{[(R)-{[(1R)-2-methyl-1-(propanoyloxy)propyl]oxy}(4-phenylbutyl)phosphoryl]acetyl}-L-proline MFCD00897699 L-Proline, 4-cyclohexyl-1-[2-[(R)-[(1R)-2-methyl-1-(1-oxopropoxy)propoxy][(1R)-4-phenylbutyl]phosphinyl]acetyl]-, (4S)- Fositen L-proline, 4-cyclohexyl-1-[2-[(R)-[[(1R)-2-methyl-1-(1-oxopropoxy)propyl]oxy][(1R)-4-phenylbutyl]phosphinyl]acetyl]-, (4S)- Fozitec Elidur

Description	Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy [1-3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Natural Products >> Alkaloid Research Areas >> Cardiovascular Disease
References	[1]. Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77(6 Pt 2): p. I74-8. [2]. Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7. [3]. Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6(4): p. 181-9.

Density	1.2±0.1 g/cm3
Boiling Point	705.7±70.0 °C at 760 mmHg
Melting Point	196-198ºC
Molecular Formula	C₃₀H₄₅NNaO₇P
Molecular Weight	563.662
Flash Point	380.6±35.7 °C
Exact Mass	563.301208
PSA	122.85000
LogP	6.09
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.532
Storage condition	-20°C Freezer

RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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