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  • DC Chemicals Limited
  • China
  • Product Name: Clorsulon
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

60200-06-8

60200-06-8 structure
60200-06-8 structure
  • Name: Clorsulon
  • Chemical Name: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
  • CAS Number: 60200-06-8
  • Molecular Formula: C8H8Cl3N3O4S2
  • Molecular Weight: 380.656
  • Catalog: analytical chemistry Standard Analytical standard
  • Create Date: 2018-03-21 08:00:00
  • Modify Date: 2024-01-02 18:36:37
  • Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].

Name 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
Synonyms Clorsulon [Spanish]
UNII-EG1ZDO6LRD
EINECS 262-100-2
Clorsulonum [Latin]
4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide
4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide
Ivomec-F
4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide
MFCD00072006
Clorsulone [French]
Clorsulon
1,3-Benzenedisulfonamide, 4-amino-6-(1,2,2-trichloroethenyl)-
Curatrem
4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide
4-Amino-6-(trichlorethenyl)-1,3-benzoldisulfonamid
MK-401
4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide
Description Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].
Related Catalog
References

[1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7.

[2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41.

Density 1.8±0.1 g/cm3
Boiling Point 651.7±65.0 °C at 760 mmHg
Melting Point 194-203°C
Molecular Formula C8H8Cl3N3O4S2
Molecular Weight 380.656
Flash Point 348.0±34.3 °C
Exact Mass 378.902191
PSA 163.10000
LogP 1.04
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.665
Storage condition 0-6°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ9090000
CHEMICAL NAME :
1,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)-
CAS REGISTRY NUMBER :
60200-06-8
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H8-Cl3-N3-O4-S2
MOLECULAR WEIGHT :
380.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
761 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS CZ9090000
HS Code 2935009090
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%