60200-06-8

60200-06-8 structure

Name: Clorsulon
Chemical Name: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
CAS Number: 60200-06-8
Molecular Formula: C₈H₈Cl₃N₃O₄S₂
Molecular Weight: 380.656
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-03-21 08:00:00
Modify Date: 2024-01-02 18:36:37
Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].

Name	4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
Synonyms	Clorsulon [Spanish] UNII-EG1ZDO6LRD EINECS 262-100-2 Clorsulonum [Latin] 4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide 4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide Ivomec-F 4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide MFCD00072006 Clorsulone [French] Clorsulon 1,3-Benzenedisulfonamide, 4-amino-6-(1,2,2-trichloroethenyl)- Curatrem 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide 4-Amino-6-(trichlorethenyl)-1,3-benzoldisulfonamid MK-401 4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide

Description	Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7. [2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	CZ9090000
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%