11076-19-0

11076-19-0 structure

Name: Bongkrekic acid
Chemical Name: bongkrekic acid
CAS Number: 11076-19-0
Molecular Formula: C₂₈H₃₈O₇
Molecular Weight: 486.59700
Catalog: Signaling Pathways Membrane Transporter/Ion Channel ATP Synthase
Create Date: 2018-09-25 16:36:12
Modify Date: 2024-01-05 18:16:39
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans[1]. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport[2].

Name	bongkrekic acid
Synonyms	Bongkrekic Acid, Triammonium Salt BONGKREKIC ACID Bongkrekic acid solution

Description	Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans[1]. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase
In Vitro	Bongkrekic acid (0-50 μM; 48 hours) stimulated formazan formation in MDA-MB-231, MCF-7 and LTED cells with EC50 of 34.14 μM, >50 μM and 2.58 μM, respectively. Bongkrekic acid (0.1-25 μM; 48 hours) decreases the living cell numbers in LTED cells and parent MCF-7 cells in a dose-dependent manner[1].
References	[1]. Mehruba Anwar, et al. Bongkrekic Acid-a Review of a Lesser-Known Mitochondrial Toxin. J Med Toxicol. 2017 Jun;13(2):173-179. [2]. C Dahout-Gonzalez, et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) [3]. Shuso Takeda, et al. Bongkrekic Acid as a Warburg Effect Modulator in Long-term Estradiol-deprived MCF-7 Breast Cancer Cells. Anticancer Res

Density	1.114g/cm3
Boiling Point	715.1ºC at 760mmHg
Melting Point	50-60°
Molecular Formula	C₂₈H₃₈O₇
Molecular Weight	486.59700
Flash Point	231ºC
Exact Mass	486.26200
PSA	121.13000
LogP	5.88560
Appearance	Lyophilized solid
Index of Refraction	1.545
Storage condition	-20°C
Water Solubility	Soluble in DMSO (up to 100 mg/ml) or in Water (up to 1 mg/ml).

CHEMICAL NAME :: 2,4,8,10,14,18,20-Docosaheptaenedioic acid, 20-(carboxymethyl)-6-methoxy-2,5,17-trimethyl-, (R-(R*,S*(E,Z,Z,E,E,Z,E)))-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TETRAB Tetrahedron. (Pergamon Press Inc., Maxwell House, Fairview Park, Elm sford, NY 10523) V.1- 1957- Volume(issue)/page/year: 26,5993,1970

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
RIDADR	NONH for all modes of transport