- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: FICZ
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: FICZ
- Price: ￥2808.0/25mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: FICZ
- Price: $550.0/100mg $900.0/250mg $1800.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: FICZ
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: INDOLO[3,2-B]CARBAZOLE-6-CARBALDEHYDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
172922-91-7
172922-91-7 structure
- Name: FICZ
- Chemical Name: 6-formylindolo a carbazole
- CAS Number: 172922-91-7
- Molecular Formula: C19H12N2O
- Molecular Weight: 284.31
- Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
- Create Date: 2018-12-02 09:48:13
- Modify Date: 2024-01-09 22:00:44
-
FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
| Name | 6-formylindolo a carbazole |
|---|---|
| Synonyms |
Indolo[3,2-b]carbazole-6-carboxaldehyde
Indolo[3,2-b]carbazole-6-carbaldehyde 6-formylindolo(3,2-b)carbazole FICZ |
| Description | FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM. |
|---|---|
| Related Catalog | |
| In Vitro | FICZ (0.01 nM-1 µM) alone or in combination with 50 nM MNF induces sustained CYP1A1 activity and leads to oxidative stress and activation of apoptosis via a mitochondrial-dependent pathway. In HepG2 cells, FICZ stimulates cell growth at low concentrations but inhibits cell growth at high concentrations[1]. FICZ (10,000-30,000 nM) significantly decreases CEH viability with an estimated LC50 (95% confidence intervals) of 14,000 nM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively[2]. FICZ treatment increases transcript expression of CYP1A1 in a dose-dependent manner in both the parental iPSC line and the CYP1A1 targeted clone[3]. CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. CYP1 enzymes plays a role in regulating biological effects of FICZ[4]. |
| Cell Assay | The cell viability of CEH treated with FICZ or TCDD is studied with the untreated cells (used as a live cell control) and sodium hypochlorite (5%)-treated cells (used as a dead cell control). This assay is based upon the bioluminescent measurement of adenosine triphosphate (ATP) that is present in all metabolically active cells. Luciferase is utilized in this method to catalyze the formation of light from ATP and luciferin. CEH are lysed 24 h after dosing and the luminescence emitted from the ATP-dependent oxidation of luciferin is measured with a LuminoSkan Ascent luminometer. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 463.8±45.0 °C at 760 mmHg |
| Molecular Formula | C19H12N2O |
| Molecular Weight | 284.31 |
| Flash Point | 191.1±34.1 °C |
| PSA | 41.79000 |
| LogP | 3.31 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.772 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |