Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PYRONINE B
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: PYRONINE B
Price: ￥248.0/5g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (6-(Diethylamino)-3H-xanthen-3-ylidine)diethylammonium chloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

2150-48-3

2150-48-3 structure

Name: PYRONINE B
Chemical Name: [6-(diethylamino)xanthen-3-ylidene]-diethylazanium,chloride
CAS Number: 2150-48-3
Molecular Formula: C₂₁H₂₇ClN₂O
Molecular Weight: 358.905
Catalog: Biochemical Biochemical reagent Biological dye
Create Date: 2018-03-23 08:00:00
Modify Date: 2024-01-04 17:54:11
Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor[1][2].

Name	[6-(diethylamino)xanthen-3-ylidene]-diethylazanium,chloride
Synonyms	Ethanaminium, N-[6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethyl-, chloride (1:1) Ethanaminium, N-[6- (diethylamino)-3H-xanthen-3-ylidene]-N-ethyl-, chloride Pyronine B,purified E tetraethylpyronin [6-(Diethylamino)-3H-xanthen-3-ylidene]diethylammonium chloride 3.6-Bis-diaethylamino-xanthylium-chlorid Pyronin B 6-(Diethylamino)-N,N-diethyl-3H-xanthen-3-iminium chloride MFCD00011932 Ammonium, [6- (diethylamino)-3H-xanthen-3-ylidene]diethyl-, chloride EINECS 218-429-9 3,6-bis-diethylamino xanthylium chloride PYRONINE B

Description	Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	Pyronin B (0-15 μM) inhibits channel activity of approximately 60% of small hydrophobic (SH) proteins at a concentration of 10 μM, and the Kd value of 6.8 μM[1]. Pyronin B (0-0.25 μM) affects RSV replication in Vero cells in a dose-dependent manner, and its TCID 50 (50% tissue culture infection dose) = 0 at the concentration of 0.25 μM[1]. Pyronin B (10 μM) can react with bromate in an oxidation reaction and the reaction rate increases dramatically with the addition of trace amounts of Ti (IV) with the characteristic absorption spectra of 555 nm[2].
References	[1]. Yan Li, et al. Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. J Virol. 2014 Oct;88(20):11899-914. [2]. Zhou Z R, et al. Study of the Catalytic Effects of Trace Titanium on Oxidation of Pyronin B with Hydrogen Peroxide and Its Application[C]//Advanced Materials Research. Trans Tech Publications Ltd, 2013, 602: 1233-1237.

Melting Point	174-176ºC
Molecular Formula	C₂₁H₂₇ClN₂O
Molecular Weight	358.905
Exact Mass	358.181183
PSA	19.39000
LogP	1.19980
Appearance	crystals \| Green needles or
Storage condition	Store at RT.
Water Solubility	Soluble in water, ethyl acetate, methyl acetate, ethylene glycol; slightly soluble in ethanol, methanol, methyl cellosolve

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP6832000

CHEMICAL NAME :: Ammonium, (6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride

CAS REGISTRY NUMBER :: 2150-48-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H27-N2-O.Cl

MOLECULAR WEIGHT :: 358.95

WISWESSER LINE NOTATION :: T C666 BO EYJ EUK2&2 MN2&2 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 1000 ppm

REFERENCE :: AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year: 87,295,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3951 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 162 (estimated) No. of Female Employees: 124 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R68
Safety Phrases	S22;S45;S24/25;S36/S37
RIDADR	NONH for all modes of transport
RTECS	BP6832000

6274-83-5

~54%

2150-48-3

Literature: WISTA LABORATORIES LTD.; CLUNAS, Scott; STRORY, John, Mervyn, David; RICKARD, Janet, Elizabeth; HORSLEY, David; HARRINGTON, Charles, Robert; WISCHIK, Claude, Michel Patent: WO2010/67078 A2, 2010 ; Location in patent: Page/Page column 65 ;

916308-37-7

~80%

2150-48-3

Literature: Han, Shulei; Chen, Yi Dyes and Pigments, 2013 , vol. 96, # 1 p. 59 - 62

7647-01-0

64-18-6

56-81-5

91-68-9

Detail

Literature: Journal of the Chemical Society, , p. 244,247

Precursor 5
6274-83-5 7647-01-0 64-18-6 56-81-5
91-68-9
DownStream 0

2150-48-3	6343-04-0
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