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Product Name: TRIHEPTANOIN
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Shanghai Jizhi Biochemical Technology Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
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620-67-7

620-67-7 structure

Name: TRIHEPTANOIN
Chemical Name: triheptanoin
CAS Number: 620-67-7
Molecular Formula: C₂₄H₄₄O₆
Molecular Weight: 428.603
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-25 08:00:00
Modify Date: 2024-01-02 18:32:38
Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1].

Name	triheptanoin
Synonyms	Triheptanoin Glycerol-1,2,3-triheptanoate TRIHEPTANION trioenanthoin Propane-1,2,3-triyl triheptanoate trienanthoin propane-1,2,3-triyl trisheptanoate 1,2,3-Propanetriyl triheptanoate glyceryl triheptanoate glycerol trienanthate 1,2,3-tris-heptanoyloxy-propane glyceroltriheptanoate triheptylin tri-heptanoi 1,2,3-Tris-heptanoyloxy-propan Heptanoic acid, 1,2,3-propanetriyl ester triheptanoicglyceride TRIOENANTHIN

Description	Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories and fatty acids to bypass the LC-FAOD enzyme deficiencies[1]. Triheptanoin can be used for the research of ataxia-telangiectasia (A-T)[2]. Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) and subsequently acetyl-CoA and propionyl-CoA that feed into the TCA cycle to supply energy[2]. Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction, including respiration and redox balance in a mouse model of Alzheimer's disease, supporting the energy failure hypothesis for that disorder[2]. Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice[3]. Animal Model: 7-8 week old male CD1 (35-40 g)[3] Dosage: 35E% oral Triheptanoin was mixed into mouse chow Administration: Given 35E% Triheptanoin treatment 10 days prior to SE induction Result: Preserved mitochondrial functions in SE mice.
References	[1]. Matt Shirley. Triheptanoin: First Approval. Drugs. 2020 Oct;80(15):1595-1600. [2]. A J Yeo, et al. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021 Dec;54:101354. [3]. Kah Ni Tan, et al. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. J Neurochem. 2018 Feb;144(4):431-442.

Density	1.0±0.1 g/cm3
Boiling Point	470.0±12.0 °C at 760 mmHg
Molecular Formula	C₂₄H₄₄O₆
Molecular Weight	428.603
Flash Point	195.5±19.6 °C
Exact Mass	428.313782
PSA	78.90000
LogP	7.73
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.457

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB2660000

CHEMICAL NAME :: Glycerol triheptanoate

CAS REGISTRY NUMBER :: 620-67-7

BEILSTEIN REFERENCE NO. :: 1807724

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H44-O6

MOLECULAR WEIGHT :: 428.68

WISWESSER LINE NOTATION :: 6VO1YOV6&1OV6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940- Volume(issue)/page/year: 40,338,1957

Hazard Codes	Xi
Risk Phrases	38
HS Code	2915900090

111-14-8

56-81-5

620-67-7

Literature: Ozaki Biochemische Zeitschrift, 1926 , vol. 177, p. 166 Proceedings of the Imperial Academy (Tokyo), vol. 2, p. 343 Chem. Zentralbl., 1926 , vol. 97, # II p. 2451

Precursor 2
111-14-8 56-81-5
DownStream 0

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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