Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (-)-QUINPIROLEHYDROCHLORIDE
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DC Chemicals Limited
China
Product Name: (-)-Quinpirole hydrochloride
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (-)-O-(9)-ALLYL-N-(9-ANTHRACENYLMETHYL)CINCHONIDINIUMBROMIDE
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85798-08-9

85798-08-9 structure

85798-08-9 structure

Name: (-)-Quinpirole hydrochloride
Chemical Name: (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline,hydrochloride
CAS Number: 85798-08-9
Molecular Formula: C₁₃H₂₂ClN₃
Molecular Weight: 255.78700
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-07-06 20:04:11
Modify Date: 2024-01-02 19:14:11
Quinpirole (Hydrochloride) is a high-affinity agonist dopamine D2/D3 receptor.

Name	(4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline,hydrochloride
Synonyms	Anandamide-d4 Quinpirole hydrochloride (USAN) QUINPIROLE HYDROCHLORIDE Quinpirole HCl

Description	Quinpirole (Hydrochloride) is a high-affinity agonist dopamine D2/D3 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine D2/D3 receptor[1].
In Vivo	DA content is left brain biased across groups, and although this asymmetry appears greater in saline controls than all drug-treated groups, there is not a significant interaction between Side and Group. When each side is considered separately it can be seen that in the left brain structure, DA levels progressively decrease with chronic quinpirole treatment, with the QQ rats differing significantly from saline controls. In contrast, right cortical DA levels are only altered significantly (increased) by acute Quinpirole. It can be found that DOPAC levels are also left brain biased across groups. However, no significant Group or interaction effects are found. Rats receiving acute Quinpirole show a selective increase in DA content and decrease in turnover ratio, relative to either saline controls or the QS group. Sensitized (QQ) rats however, have elevated DOPAC levels in comparison to the acute quinpirole group. In striatum as well, all three measures of DA function differed significantly across groups (DA, F3,33=6.27, P=0.0020; DOPAC, F3,33=7.98, P=0.0004; turnover ratio, F3,33=16.85, P<0.0001). In the acute quinpirole rats, both DOPAC and turnover ratio are significantly reduced relative to all other groups. In QQ rats, DOPAC levels are significantly greater than all other groups, while for turnover ratio, both chronic quinpirole groups were increased compared to both chronic saline groups[1].
Animal Admin	Rat[1] 36 male Long-Evans rats are injected daily for 12 days with either saline or Quinpirole (Hydrochloride) (quinpirole HCl: 0.5 mg/kg, s.c., n=18/condition), and placed immediately in Omnitech activity monitors (60×60×40 cm) for 90 min. On the final test day, half the rats in each chronic condition received saline and half Quinpirole (n=9/group). The four groups therefore represented saline controls (SS), acute Quinpirole (SQ), sensitized Quinpirole (no drug)(QS) and sensitized Quinpirole (drug) (QQ). 30 min after the final injection, each rat is removed from the activity monitors to a nearby room and killed immediately by decapitation. This time point is chosen to dissociate the behavioural effects of quinpirole between groups, since acute quinpirole produces inhibition of activity at this time, while chronic quinpirole is associated with pronounced hyperlocomotion at 30 min[1].
References	[1]. Sullivan RM, et al. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience. 1998 Apr;83(3):781-9.

Density	1.07g/cm3
Boiling Point	383.9ºC at 760 mmHg
Molecular Formula	C₁₃H₂₂ClN₃
Molecular Weight	255.78700
Flash Point	186ºC
Exact Mass	255.15000
PSA	31.92000
LogP	2.73880
Index of Refraction	1.546

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR0809270

CHEMICAL NAME :: 1H-Pyrazolo(3,4-g)quinolone, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, monohydrochloride, (4aR-trans)-

CAS REGISTRY NUMBER :: 85798-08-9

LAST UPDATED :: 199403

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H21-N3.Cl-H

MOLECULAR WEIGHT :: 255.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 ug/kg

SEX/DURATION :: female 10-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 44,487,1993

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RIDADR	NONH for all modes of transport
RTECS	UR0809270