65914-84-3

65914-84-3 structure

Name: 1-Stearoyl-2-arachidonoyl-sn-glycerol
Chemical Name: 1-stearoyl-2-arachidonoyl-sn-glycerol
CAS Number: 65914-84-3
Molecular Formula: C₄₁H₇₂O₅
Molecular Weight: 645.007
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2018-12-25 14:04:40
Modify Date: 2024-01-09 08:29:28
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].

Name	1-stearoyl-2-arachidonoyl-sn-glycerol
Synonyms	5,8,11,14-Eicosatetraenoic acid, (1S)-2-hydroxy-1-[[(1-oxooctadecyl)oxy]methyl]ethyl ester, (5Z,8Z,11Z,14Z)- (1-hydroxy-3-octadecanoyloxypropan-2-yl) icosa-5,8,11,14-tetraenoate (2S)-1-Hydroxy-3-(stearoyloxy)-2-propanyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate 18:0/20:4-DG 1-stearoyl-2-arachidonoylglycerol 2-O-arachidonoyl-1-O-stearoyl-sn-glycerol 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-[[(1-oxooctadecyl)oxy]methyl]ethyl ester, (5Z,8Z,11Z,14Z)- (2S)-1-hydroxy-3-(stearoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate 1-stearoyl-2-arachidonyl glycerol 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol MFCD00070361 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol 1-stearoyl-2-arachidonyl-sn-glycerol 1-STEAROYL-2-ARACHIDONOYL-SN-GLYCEROL 1-Hydroxy-3-(stearoyloxy)-2-propanyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate DG(18:0/20:4(5Z,8Z,11Z,14Z)/0:0)[iso2]

Description	1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKC[2]
In Vitro	1-Stearoyl-2-arachidonoyl-sn-glycerol (0.3-3 μM) augments nonselective cation channel (NSCC) activity in airway smooth muscle cells[1]. 1-Stearoyl-2-arachidonoyl-sn-glycerol (0-5 μM) exerts significantly stimulatory effects on activation of PKCα, PKCδ, PKCγ, PKCε and PKCβI[2].
References	[1]. Song T, et, al. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1455-66. [2]. Madani S, et, al. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J. 2001 Dec;15(14):2595-601. [3]. Glasmacher S, et, al. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808.

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