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5534-95-2

5534-95-2 structure
5534-95-2 structure
  • Name: Pentagastrin
  • Chemical Name: pentagastrin
  • CAS Number: 5534-95-2
  • Molecular Formula: C37H49N7O9S
  • Molecular Weight: 767.891
  • Catalog: API Diagnostic medication Organ function test agent
  • Create Date: 2018-02-19 08:00:00
  • Modify Date: 2024-01-02 04:28:38
  • pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally，which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]
Name pentagastrin
Synonyms pentagastrine
Pentagastrin
petogasrin
GRP
Gastrodiagnost
ay6608
N-(tert-Butoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
EINECS 226-889-7
N-Carboxy-β-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide N-tert-butyl ester
Peptavlon
petavlon
MFCD00076515
L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
N-[N-[N-[N-(N-tert-Butoxycarbonyl-b-alanyl)-L-tryptophanyl]-L-methionyl ]-L-aspartyl]-L-phenylalaninamide
N-(a-Carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-ylpropionamido]-4-(methylthio)butyramido]succinamic Acid-N-tert-Butyl Ester
N-Carboxy-b-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide N-tert-Butyl Ester
lanineamide
N-[(1,1-Dimethylethoxy)carbonyl]-b-alanyl-L-tryptophyl-L-methionyl-L-a-aspartyl-L-phenylalaninamide
L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
Boc-β-ala-try-met-asp-phe(nh2)
Boc-b-Ala-Try-Met-Asp-Phe(NH2)
Description pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally，which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]
Related Catalog
References

[1]. Loy F et al. Ultrastructural evidence of a secretory role for melatonin in the human parotid gland.J Physiol Pharmacol, 2015 Dec, 66(6):847-53.

[2]. Abdel-Salam O et al. Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med, 2016 May, 9(5):413-9.

[3]. Czekaj R et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol, 2016 Apr, 67(2):261-75.
Density 1.3±0.1 g/cm3
Boiling Point 1196.6±65.0 °C at 760 mmHg
Melting Point 229-230° (dec)
Molecular Formula C37H49N7O9S
Molecular Weight 767.891
Flash Point 677.5±34.3 °C
Exact Mass 767.331238
PSA 276.21000
LogP 3.03
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.604
Storage condition -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY2970000
CHEMICAL NAME :
Alaninamide, N-carboxy-beta-alanyl-L-tryptophyl-L-methionyl-L-aspa rtylphenyl-, N-tert-butyl ester, L-
CAS REGISTRY NUMBER :
5534-95-2
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C37-H49-N7-O9-S
MOLECULAR WEIGHT :
767.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
5 ug/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 289,470,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,612,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,776,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982
Hazard Codes T
Risk Phrases 61-36/38-20/21
Safety Phrases S53-S45-S36/37/39-S22
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS AY2970000

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