480-44-4

480-44-4 structure

Name: Acacetin
Chemical Name: 5,7-dihydroxy-4'-methoxyflavone
CAS Number: 480-44-4
Molecular Formula: C₁₆H₁₂O₅
Molecular Weight: 284.263
Catalog: Natural product Flavonoids
Create Date: 2018-06-29 09:34:05
Modify Date: 2024-01-02 17:39:27
1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration

Name	5,7-dihydroxy-4'-methoxyflavone
Synonyms	Linarigenin 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one Acacetin 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one 5,7-Dihydroxy-4'-methoxyflavone Apigenin-4'-methyl Ether 4'-O-Methylapigenin Buddleoflavonol MFCD00016936 4'-Methoxyapigenin 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)- Apigenin 4'-methyl ether EINECS 207-552-3

Description	1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127. [2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3002000
HS Code	2914509090

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%