353483-92-8

353483-92-8 structure

Name: TQS
Chemical Name: 4-(1-Naphthyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-s ulfonamide
CAS Number: 353483-92-8
Molecular Formula: C₂₂H₂₀N₂O₂S
Molecular Weight: 376.47100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2017-02-04 06:09:38
Modify Date: 2024-01-19 00:59:48
TQS is a α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator. TQS can be used for the research of neuroinflammatory pain[1].

Name	4-(1-Naphthyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-s ulfonamide
Synonyms	PSB 11 hydrochloride

Description	TQS is a α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator. TQS can be used for the research of neuroinflammatory pain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	nAChR[1]
In Vivo	TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus[1]. Animal Model: Male C57BL/6J mice[1] Dosage: 1 or 4 mg/kg Administration: I.p. Result: Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus.
References	[1]. Abbas M, et al. The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice. Drug Discov Ther. 2017;11(4):206-211.

Hazard Codes	Xi