Name | 3-(1H-Imidazol-4-yl)propyl N-[2-(4-iodophenyl)ethyl]carbamimidoth ioate dihydrobromide |
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Synonyms | L-BMAA hydrochloride |
Description | Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1]. |
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Related Catalog | |
Target |
H3 Receptor:0.32 nM (Kd) |
In Vitro | Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor[2]. Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC50 of 1.57±0.3 μM[3]. |
In Vivo | Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits[4]. Animal Model: New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg[4] Dosage: 1 μg/kg Administration: Administered through intramuscular (i.m.); b.i.d.; for 10 days Result: Could influence a detectable antibody response to SRBC. |
References |
Molecular Formula | C15H21Br2IN4S |
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Molecular Weight | 576.13200 |
Exact Mass | 573.89000 |
PSA | 89.86000 |
LogP | 5.85400 |