7082-21-5

7082-21-5 structure

Name: Terodiline hydrochloride
Chemical Name: N-tert-butyl-4,4-diphenylbutan-2-amine,hydrochloride
CAS Number: 7082-21-5
Molecular Formula: C₂₀H₂₈ClN
Molecular Weight: 317.89600
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2016-03-09 00:00:00
Modify Date: 2024-01-09 16:22:24
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

Name	N-tert-butyl-4,4-diphenylbutan-2-amine,hydrochloride
Synonyms	Propylamine,N-tert-butyl-1-methyl-3,3-diphenyl-,hydrochloride N-tert-Butyl-1-methyl-3,3-diphenylpropylamine hydrochloride TERODILINE HYDROCHLORIDE Bicor N-t-Butyl-1-methyl-3,3-diphenylpropylamine hydrochloride Terodiline chloride TD-758 Terodiline HCl

Description	Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	mAChR[1] Ca2+ channel[1]
In Vivo	Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1]. Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1] Dosage: 80 mg/kg Administration: Administered S.C. Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
References	[1]. Noronha-Blob L, et al. (+/-)-Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion. Eur J Pharmacol. 1991 Aug 29;201(2-3):135-42.

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H319-H400
Precautionary Statements	P273-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn,N
Risk Phrases	22-36-50
RIDADR	UN 3077 9/PG 3
RTECS	UH9970000