1197958-12-5

1197958-12-5 structure

Name: AP26113
Chemical Name: 5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
CAS Number: 1197958-12-5
Molecular Formula: C₂₆H₃₄ClN₆O₂P
Molecular Weight: 529.014
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2018-10-17 17:13:57
Modify Date: 2024-01-02 10:06:49
ALK-IN-1 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

Name	5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
Synonyms	2,4-Pyrimidinediamine, 5-chloro-N-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N-[2-(dimethylphosphinyl)phenyl]- 5-Chloro-N-{4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl}-N-[2-(dimethylphosphoryl)phenyl]-2,4-pyrimidinediamine AP26113 Brigatinib ALK-IN-1

Description	ALK-IN-1 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Research Areas >> Cancer
References	[1]. Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1 [2]. Victor M. Rivera, Frank Wang, Rana Anjum, Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Research: April 15, 2012; Volume 72, Issue 8, Supplement 1