322473-89-2
322473-89-2 structure
- Name: SCH 221510
- Chemical Name: 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
- CAS Number: 322473-89-2
- Molecular Formula: C28H31NO
- Molecular Weight: 397.55
- Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
- Create Date: 2017-07-09 06:50:06
- Modify Date: 2024-01-02 19:37:24
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SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1].
| Name | 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol |
|---|---|
| Synonyms |
MM 77 dihydrochloride
3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol SCH 221510 |
| Description | SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 12 nM (NOP)[1] |
| References |
| Molecular Formula | C28H31NO |
|---|---|
| Molecular Weight | 397.55 |
| Exact Mass | 397.24100 |
| PSA | 23.47000 |
| LogP | 5.84530 |
|
~%
322473-89-2 |
| Literature: Ho, Ginny D.; Anthes, John; Bercovici, Ana; Caldwell, John P.; Cheng, Kuo-Chi; Cui, Xiaoming; Fawzi, Ahmad; Fernandez, Xiomara; Greenlee, William J.; Hey, John; Korfmacher, Walter; Lu, Sherry X.; McLeod, Robbie L.; Ng, Fay; Torhan, April Smith; Tan, Zheng; Tulshian, Deen; Varty, Geoffrey B.; Xu, Xiaoying; Zhang, Hongtao Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2519 - 2523 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |