Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ikarugamycin
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Ikarugamycin
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

36531-78-9

36531-78-9 structure

36531-78-9 structure

Name: Ikarugamycin
Chemical Name: ikarugamycin
CAS Number: 36531-78-9
Molecular Formula: C₂₉H₃₈N₂O₄
Molecular Weight: 478.62
Catalog: Research Areas Others
Create Date: 2018-09-08 10:44:07
Modify Date: 2024-01-04 19:05:53
Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1].

Name	ikarugamycin
Synonyms	14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)- (3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-Ethyl-28-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.0.0.0]octacosa-1(28),3,13,18-tetraene-2,20,27-trione Ikarugamycin tu-6239 c3

Description	Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Clathrin-mediated endocytosis[1]
In Vitro	Ikarugamycin has an IC50 of 2.7 μM in H1299 cells[1].
References	[1]. Elkin SR, et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic. 2016 Oct;17(10):1139-49.

Density	1.2±0.1 g/cm3
Boiling Point	741.9±60.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₈N₂O₄
Molecular Weight	478.62
Flash Point	402.5±32.9 °C
Exact Mass	478.283173
PSA	95.50000
LogP	5.05
Vapour Pressure	0.0±5.6 mmHg at 25°C
Index of Refraction	1.604
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI0625500

CHEMICAL NAME :: Ikarugamycin

CAS REGISTRY NUMBER :: 36531-78-9

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C29-H38-N2-O4

MOLECULAR WEIGHT :: 478.69

WISWESSER LINE NOTATION :: T I5 H6 F5-17-5 A CV UVM D&MV DU NU SU C&HTTTT&J AQ L2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	T
RIDADR	UN 2811 6.1 / PGIII

Precursor 2
131196-56-0 131196-57-1
DownStream 0