Ikarugamycin

Modify Date: 2024-01-04 19:05:53

Ikarugamycin Structure
Ikarugamycin structure
 Common Name Ikarugamycin
CAS Number 36531-78-9 Molecular Weight 478.62
Density 1.2±0.1 g/cm3 Boiling Point 741.9±60.0 °C at 760 mmHg
Molecular Formula C29H38N2O4 Melting Point N/A
MSDS Chinese USA Flash Point 402.5±32.9 °C
Symbol GHS06
GHS06		 Signal Word Danger

 Use of Ikarugamycin


Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1].

 Names

Name ikarugamycin
Synonym More Synonyms

 Ikarugamycin Biological Activity

Description Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1].
Related Catalog
Target

Clathrin-mediated endocytosis[1]

In Vitro Ikarugamycin has an IC50 of 2.7 μM in H1299 cells[1].
References

[1]. Elkin SR, et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic. 2016 Oct;17(10):1139-49.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 741.9±60.0 °C at 760 mmHg
Molecular Formula C29H38N2O4
Molecular Weight 478.62
Flash Point 402.5±32.9 °C
Exact Mass 478.283173
PSA 95.50000
LogP 5.05
Vapour Pressure 0.0±5.6 mmHg at 25°C
Index of Refraction 1.604
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI0625500
CHEMICAL NAME :
Ikarugamycin
CAS REGISTRY NUMBER :
36531-78-9
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C29-H38-N2-O4
MOLECULAR WEIGHT :
478.69
WISWESSER LINE NOTATION :
T I5 H6 F5-17-5 A CV UVM D&MV DU NU SU C&HTTTT&J AQ L2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T
RIDADR UN 2811 6.1 / PGIII

 Synthetic Route

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles7

More Articles
Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB).

PLoS Negl. Trop. Dis. 9 , e0004041, (2015)

Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vacci...

Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold.

J. Exp. Bot. 59(11) , 3051-68, (2008)

Positively charged nanogold was used as a probe to trace the internalization of plasma membrane (PM) domains carrying negatively charged residues at an ultrastructural level. The probe revealed distin...

Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold.

J. Cell Sci. 120(Pt 21) , 3804-19, (2007)

In an attempt to dissect endocytosis in Nicotiana tabacum L. pollen tubes, two different probes--positively or negatively charged nanogold--were employed. The destiny of internalized plasma membrane d...

 Synonyms

14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-
(3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-Ethyl-28-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.0.0.0]octacosa-1(28),3,13,18-tetraene-2,20,27-trione
Ikarugamycin
tu-6239 c3
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