36098-33-6

36098-33-6 structure

Name: F16
Chemical Name: 3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
CAS Number: 36098-33-6
Molecular Formula: C₁₆H₁₅IN₂
Molecular Weight: 362.208
Catalog: Research Areas Cancer
Create Date: 2016-03-21 05:49:58
Modify Date: 2024-01-06 13:47:20
F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. 1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.3, F16 caused apoptosis in A6 cells.4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.

Name	3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
Synonyms	4-[(e)-2-(1h-indol-3-yl)-vinyl]-1-methyl-pyridinium in1341 Pyridinium, 4-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-, iodide (1:1) Pyridinium, 4-(2-indol-3-ylvinyl)-1-methyl-, iodide 4-[(E)-2-(1H-Indol-3-yl)vinyl]-1-methylpyridinium iodide F16

Description	F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. 1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.3, F16 caused apoptosis in A6 cells.4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42. [2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.