116371-67-6

116371-67-6 structure

Name: Gemcitabine Monophosphate Formate Salt
Chemical Name: [(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate,formic acid
CAS Number: 116371-67-6
Molecular Formula: C₉H₁₂F₂N₃O₇P
Molecular Weight: 343.17800
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-02-22 08:00:00
Modify Date: 2024-01-08 14:32:22
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate shows synergistic anti-cancer effects[1][2].

Name	[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate,formic acid
Synonyms	gemcitabine 5'-monophosphate 2'-deoxy-2',2'-difluorocytidine 5-monophosphate 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Formate Gemcitabine Monophosphate Formate Salt Gemcitabine monophosphate

Description	Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate shows synergistic anti-cancer effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. [2]. Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611.

103882-84-4

~90%

116371-67-6

Literature: Lohman, Gregory J.S.; Stubbe, Joanne Biochemistry, 2010 , vol. 49, # 7 p. 1404 - 1417

95058-81-4

~53%

116371-67-6

Literature: Cappellacci; Franchetti; Vita; Petrelli; Grifantini Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 5 p. 460 - 468

Precursor 2
103882-84-4 95058-81-4
DownStream 0