64748-79-4

64748-79-4 structure

Name: Azumolene
Chemical Name: 1-[[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione
CAS Number: 64748-79-4
Molecular Formula: C₁₃H₉BrN₄O₃
Molecular Weight: 349.14000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-04-06 08:00:00
Modify Date: 2024-01-02 18:17:32
Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2].

Name	1-[[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione
Synonyms	Azumolenum Azumolenum [Latin] 1-[5-(4-bromo-phenyl)-oxazol-2-ylmethyleneamino]-imidazolidine-2,4-dione Azumolene Azumoleno Azumolene [INN] 1-(((5-(4-bromophenyl)-2-oxazolyl)methylene)amino)-2,4-imidazolidinedione UNII-5U7IO9CV80 Azumoleno [Spanish]

Description	Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Metabolic Disease
In Vitro	Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca2+ store depletion in mouse myotubes and adult muscle fibers[2].
In Vivo	The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene[1].
References	[1]. G C Leslie, et al. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br J Pharmacol. 1989 Aug;97(4):1151-6. [2]. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633.

HS Code	2934999090

64748-80-7

~68%

64748-79-4

Literature: White, R.L.; Wessels, F.L.; Schwan, T.J.; Ellis, K.O. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 263 - 266

64748-89-6

64748-79-4

Literature: White, R.L.; Wessels, F.L.; Schwan, T.J.; Ellis, K.O. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 263 - 266

64748-90-9

64748-79-4

Literature: White, R.L.; Wessels, F.L.; Schwan, T.J.; Ellis, K.O. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 263 - 266

Precursor 3
64748-80-7 64748-89-6 64748-90-9
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%