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76-38-0

76-38-0 structure
76-38-0 structure
  • Name: Ethane,2,2-dichloro-1,1-difluoro-1-methoxy-
  • Chemical Name: methoxyflurane
  • CAS Number: 76-38-0
  • Molecular Formula: C3H4Cl2F2O
  • Molecular Weight: 164.96600
  • Catalog: API Anesthetic Agents General anesthetics
  • Create Date: 2018-12-29 23:00:06
  • Modify Date: 2024-01-03 13:45:26
  • Methoxyflurane is a halogenated volatile anaesthetic agent with potent analgesic effects at sub-anaesthetic doses. Methoxyflurane widely used as an open-circuit anaesthetic in small laboratory animals for several decades. Methoxyflurane has the risk of nephrotoxicity[1][2].
Name methoxyflurane
Synonyms MFCD00040144
2,2-dichloro-1,1-difluoro-1-methoxyethane
EINECS 200-956-0
2,2-Dichloro-1,1-Difluoroethyl Methyl Ether
Description Methoxyflurane is a halogenated volatile anaesthetic agent with potent analgesic effects at sub-anaesthetic doses. Methoxyflurane widely used as an open-circuit anaesthetic in small laboratory animals for several decades. Methoxyflurane has the risk of nephrotoxicity[1][2].
Related Catalog
In Vitro Methoxyflurane is delivered via a hand-held inhaler[3].
In Vivo The developmental toxicity of trace, subanesthetic, and anesthetic exposure to Methoxyflurane is examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of Methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of Methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring[4].
References

[1]. Occupational exposure to methoxyflurane administered for procedural sedation: an observational study of 40 exposures. Br J Anaesth. 2018 Jun;120(6):1435-1437.

[2]. Porter KM, et al. The role of inhaled methoxyflurane in acute pain management. Open Access Emerg Med. 2018 Oct 18;10:149-164.

[3]. Methoxyflurane nephrotoxicity. JAMA. 1971 Aug 16;217(7):958-9.

[4]. Wharton RS, et al., Developmental toxicity of methoxyflurane in mice. Anesth Analg. 1980 Jun;59(6):421-5.
Density 1.4262
Boiling Point 103 °C
Melting Point -36°C
Molecular Formula C3H4Cl2F2O
Molecular Weight 164.96600
Flash Point 37°C
Exact Mass 163.96100
PSA 9.23000
LogP 2.02930
Index of Refraction 1.386
Storage condition -70°C
Stability Stability

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KN7820000
CHEMICAL NAME :
Ether, 2,2-dichloro-1,1-difluoroethyl methyl
CAS REGISTRY NUMBER :
76-38-0
BEILSTEIN REFERENCE NO. :
1737766
LAST UPDATED :
199710
DATA ITEMS CITED :
34
MOLECULAR FORMULA :
C3-H4-Cl2-F2-O
MOLECULAR WEIGHT :
164.97
WISWESSER LINE NOTATION :
GYGXFFO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
3500 ppm/1H
TOXIC EFFECTS :
Kidney, Ureter, Bladder - renal function tests depressed
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33500 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21500 mg/m3
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
3600 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
34 gm/m3
TOXIC EFFECTS :
Behavioral - antipsychotic
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 ppm/24H/14W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48600 mg/m3/4H/30D-I
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/8H
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
400 ppm/8H
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
2 ppm/4H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
2000 ppm/4H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Bird - chicken
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 12,366,1976 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 TOXICOLOGY REVIEW ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year: 16,67,1976 TOXICOLOGY REVIEW KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972- Volume(issue)/page/year: 10,82,1976 TOXICOLOGY REVIEW CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86. Volume(issue)/page/year: 19,152,1972 TOXICOLOGY REVIEW ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950- Volume(issue)/page/year: 25,411,1974 TOXICOLOGY REVIEW AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 57,328,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 2 ppm (14 mg/m3) JAN 1993 OEL-RUSSIA:STEL 200 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHOXYFLURANE-air:CL 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82904 No. of Facilities: 627 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 8095 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82904 No. of Facilities: 2120 (estimated) No. of Industries: 2 No. of Occupations: 14 No. of Employees: 32772 (estimated) No. of Female Employees: 18210 (estimated)
Hazard Codes Xi
Risk Phrases R10
Safety Phrases S23-S24/25
RIDADR 3271
RTECS KN7820000
Packaging Group III
Hazard Class 3
67-56-1 structure

67-56-1

79-35-6 structure

79-35-6

~%

76-38-0 structure

76-38-0

Literature: Journal of the American Chemical Society, , vol. 73, p. 861
79-35-6 structure

79-35-6

124-41-4 structure

124-41-4

~%

76-38-0 structure

76-38-0

Literature: Journal of the American Chemical Society, , vol. 70, p. 431

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title: CAS No. 76-38-0 | Chemsrc address: https://www.chemsrc.com/en/baike/444329.html

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