64704-41-2

64704-41-2 structure

Name: Granuliberin-R
Chemical Name: Granuliberin R
CAS Number: 64704-41-2
Molecular Formula: C₆₉H₁₀₃N₁₉O₁₄
Molecular Weight: 1422.68000
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-12-18 10:10:18
Modify Date: 2024-01-07 08:52:08
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine[1][2].

Name	Granuliberin R
Synonyms	granuliberin r

Description	Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Granuliberin R (10 μg/mL) does not alter the release of catecholamines and adenine nucleotides from cultured adrenal chromaffin cells, while the Mastoparan (10 μg/mL) increases both of them[3].
In Vivo	Granuliberin R (0.1 mg/mL, 1 μg/mL, and 10 ng/mL; injection; single dose for 60 s) interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells when treatment is conducted into rats mandibular gingiva in the vicinity of the right mental foramen[4].
References	[1]. Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2464-5. [2]. Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):492-8. [3]. Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):217-27. [4]. Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8(3):727-34.

Molecular Formula	C₆₉H₁₀₃N₁₉O₁₄
Molecular Weight	1422.68000
Exact Mass	1421.79000
PSA	535.89000
LogP	4.01660
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
RIDADR	NONH for all modes of transport
WGK Germany	3.0

Precursor 2
74509-20-9 70874-09-8
DownStream 0

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