Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Physalaemin
Price:
Purity: 97.0%
Stocking Period: 10 Day
Contact: Yang

Nanjing Peptide Biotech Ltd
China
Product Name: Physalaemin
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PHYSALAEMIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

2507-24-6

2507-24-6 structure

2507-24-6 structure

Name: Physalaemin
Chemical Name: Physalaemin
CAS Number: 2507-24-6
Molecular Formula: C₅₈H₈₄N₁₄O₁₆S
Molecular Weight: 1265.44000
Catalog: Peptides
Create Date: 2017-07-10 23:04:37
Modify Date: 2024-01-10 21:37:34
Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

Name	Physalaemin
Synonyms	pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2 PHYSALAEMIN

Description	Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Natural Products >> Others Research Areas >> Neurological Disease Peptides
Target	Neurokinin-1 (NK1) receptor[1]
In Vitro	Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized[1]. Physalaemin is a bradykinin potentiating peptide (BPP-5a)[2].
References	[1]. Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. [2]. Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31.

Density	1.331g/cm3
Boiling Point	1743.2ºC at 760mmHg
Molecular Formula	C₅₈H₈₄N₁₄O₁₆S
Molecular Weight	1265.44000
Flash Point	1008.1ºC
Exact Mass	1264.59000
PSA	506.34000
LogP	2.11080
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.59
Storage condition	-20°C

WGK Germany	3