- GL Biochem (Shanghai) Ltd.
- China
- Product Name: R-G-D-C
- Price: $Inquiry/1g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Nanjing Peptide Biotech Ltd
- China
- Product Name: RGDC
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: H-ARG-GLY-ASP-CYS-OH
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
109292-46-8
109292-46-8 structure
- Name: H-Arg-Gly-Asp-Cys-OH trifluoroacetate salt
- Chemical Name: h-arg-gly-asp-cys-oh
- CAS Number: 109292-46-8
- Molecular Formula: C15H27N7O7S
- Molecular Weight: 449.48300
- Catalog: Peptides
- Create Date: 2018-02-11 08:00:00
- Modify Date: 2024-01-04 17:26:13
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Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding.
| Name | h-arg-gly-asp-cys-oh |
|---|---|
| Synonyms |
ARG-GLY-ASP-CYS
REF DUPL: H-Arg-Gly-Asp-Cys-OH RGDC R-G-D-C |
| Description | Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding. |
|---|---|
| Related Catalog | |
| In Vitro | RGDC immobilizes peptide onto DAH-CMTMC is found to be about 15.3 μg/mg of chitosan derivative by amino acid analysis (AAA). RGDC-functionalized chitosan may lead to enhanced wound healing (viability >140%). RGDC-functionalizes chitosan derivatives exhibit in vitro wound healing properties by enhancing fibroblast proliferation and adhesion. RGDC-DAH-CMTMC favors cell growth and an increase in cellular proliferation compared to the control cells[1]. |
| Cell Assay | Human precursor dermal fibroblasts (HDF, human dermal progenitor cells, 12 week male donor) are use in the assay. WST-1 assay is used to assess the viability of HDF when incubated with chitosan derivatives. For this study, HDF are seeded in a 96-well plate at a density of 6×103 cells/cm2. To each well, 100 μL of cell suspension is added and incubated for 48 h in order to allow cell attachment. DMEM is then replaced by 100 μL of CMTMC and RGDC-DAH-CMTMC suspension at concentrations of 0.25 mg/mL, 0.5 mg/mL and 1 mg/mL, respectively. Cell viability under polymer incubation is evaluated during 2, 4 and 7 days. SDS (1%) is used as negative control. The polymer solution is changed every 3 days. 100 μL of WST-1 (1:10 dilution in DMEM) are added in each well after removing the polymer suspension and incubated for 0.5-2 h. Absorbance is recorded with a BioTek Microplate reader at two different wavelengths (450 and 690 nm). The viability is presented as percentage compared to the positive control group (cells in DMEM supplemented with 10% fetal calf serum). All experiments are carried out in triplicates. |
| References |
| Molecular Formula | C15H27N7O7S |
|---|---|
| Molecular Weight | 449.48300 |
| Exact Mass | 449.16900 |
| PSA | 288.62000 |
| Storage condition | 2-8℃ |