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35050-55-6

35050-55-6 structure
35050-55-6 structure
  • Name: Tomaymycin
  • Chemical Name: 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one,2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-,(2E,11R,11aS)
  • CAS Number: 35050-55-6
  • Molecular Formula: C16H20N2O4
  • Molecular Weight: 304.34100
  • Catalog: Research Areas Infection
  • Create Date: 2016-05-08 03:01:50
  • Modify Date: 2024-01-09 23:50:07
  • Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria[1][2].
Name 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one,2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-,(2E,11R,11aS)
Description Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria[1][2].
Related Catalog
Target

Antibiotic[1][2]

In Vivo Tomaymycin, an antiphage antibiotic is produced by cultivation of Streptomyces achromogenes var. tomaymyceticus in a lactose-bouillon medium enriched with yeast extract and phosphate salts. The antiphage activity is strong against Escherichia coli T1, T3 phages and Bacillus subtilis M-2, SP-10 phages. The LD50 (i.p.) of tomaymycin for mice is estimated at 3.0 mg/kg.
References

[1]. F L Boyd, et al. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 1990 Mar 6;29(9):2387-403.

[2]. K Arima, et al. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo). 1972 Aug;25(8):437-44.
Density 1.32g/cm3
Boiling Point 541.2ºC at 760 mmHg
Molecular Formula C16H20N2O4
Molecular Weight 304.34100
Flash Point 281.1ºC
Exact Mass 304.14200
PSA 71.03000
LogP 2.03550
Index of Refraction 1.622

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY8533000
CHEMICAL NAME :
5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy- 7,11-dimethoxy-, (11R-(2E,11-alpha,11a-beta))-
CAS REGISTRY NUMBER :
35050-55-6
LAST UPDATED :
199509
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H20-N2-O4
MOLECULAR WEIGHT :
304.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3540 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
100 ng/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2819,1983

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title: CAS No. 35050-55-6 | Chemsrc address: https://www.chemsrc.com/en/baike/446074.html

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