6621-92-7

6621-92-7 structure

Name: 3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone
Chemical Name: 3-[(2,4-dihydroxyphenyl)methylidene]-5-(4-methoxyphenyl)furan-2-one
CAS Number: 6621-92-7
Molecular Formula: C₁₈H₁₄O₅
Molecular Weight: 310.30100
Catalog: Signaling Pathways Immunology/Inflammation FLAP
Create Date: 2016-05-16 04:37:02
Modify Date: 2024-02-01 17:05:44
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX[1].

Name	3-[(2,4-dihydroxyphenyl)methylidene]-5-(4-methoxyphenyl)furan-2-one

Description	ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> FLAP Research Areas >> Inflammation/Immunology
Target	FLAP[1]
References	[1]. Cerchia C et al. Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. Eur J Med Chem. 2023 Nov 8;263:115932.