3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone

Modify Date: 2024-02-01 17:05:44

3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone structure	Common Name	3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone
	CAS Number	6621-92-7	Molecular Weight	310.30100
	Density	1.408g/cm3	Boiling Point	617.2ºC at 760 mmHg
	Molecular Formula	C₁₈H₁₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	231.7ºC

Use of 3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone

ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX[1].

Name	3-[(2,4-dihydroxyphenyl)methylidene]-5-(4-methoxyphenyl)furan-2-one

Description	ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> FLAP Research Areas >> Inflammation/Immunology
Target	FLAP[1]
References	[1]. Cerchia C et al. Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. Eur J Med Chem. 2023 Nov 8;263:115932.

Density	1.408g/cm3
Boiling Point	617.2ºC at 760 mmHg
Molecular Formula	C₁₈H₁₄O₅
Molecular Weight	310.30100
Flash Point	231.7ºC
Exact Mass	310.08400
PSA	75.99000
LogP	3.08770
Index of Refraction	1.701

3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone

Use of 3-(2,4-Dihydroxybenzylidene)-5-(4-methoxyphenyl)-2(3H)-furanone

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