64369-13-7
64369-13-7 structure
- Name: HepIn-13
- Chemical Name: 2-(4-Brom-phenyl)-2,3-dihydro-1H-perimidin
- CAS Number: 64369-13-7
- Molecular Formula: C17H13BrN2
- Molecular Weight: 325.20300
- Catalog: Research Areas Cancer
- Create Date: 2016-10-02 21:49:08
- Modify Date: 2024-01-10 09:36:07
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Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1].
| Name | 2-(4-Brom-phenyl)-2,3-dihydro-1H-perimidin |
|---|---|
| Synonyms |
1h-naphth[1,2-e][1,3]oxazine,2-(4-bromophenyl)-2,3-dihydro
2-(4-bromo-phenyl)-2,3-dihydro-1H-perimidine 2-<4-Brom-phenyl>-2.3-dihydro-1H-naphth<1.2-e>-1.3-oxazin 2-(4-bromo-phenyl)-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine 2-(4-bromophenyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine |
| Description | Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.33 μM (Hepsin) |
| In Vitro | Hepln-13 (10 µM; 2 hours; 293 cells) inhibits cleavage[1]. Western Blot Analysis[1] Cell Line: 293 cells Concentration: 10 µM Incubation Time: 2 hours Result: Inhibited cleavage. |
| In Vivo | HepIn-13 displays dose dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes and blocks prostate cancer metastasis[1]. |
| References |
| Density | 1.444g/cm3 |
|---|---|
| Boiling Point | 533.3ºC at 760 mmHg |
| Molecular Formula | C17H13BrN2 |
| Molecular Weight | 325.20300 |
| Flash Point | 276.4ºC |
| Exact Mass | 324.02600 |
| PSA | 24.06000 |
| LogP | 5.41450 |
| Index of Refraction | 1.688 |
