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72103-53-8

72103-53-8 structure
72103-53-8 structure
  • Name: Tuftsin
  • Chemical Name: Tuftsin diacetate
  • CAS Number: 72103-53-8
  • Molecular Formula: C25H48N8O10
  • Molecular Weight: 620.70
  • Catalog: Peptides
  • Create Date: 2018-08-23 16:51:29
  • Modify Date: 2024-01-14 09:56:12
  • Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator.

Name Tuftsin diacetate
Synonyms tuftsin acetate salt hydrate
MFCD00133887
THR-LYS-PRO-ARG ACETATE SALT
H-THR-LYS-PRO-ARG-OH ACOH
tuftsin acetate
H-THR-LYS-PRO-ARG-OH ACETATE SALT
TUFTSIN ACETATE SALT
Tuftsin
Tuftsin (diacetate)
Description Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator.
Related Catalog
In Vitro Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes[1]. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors[2].
References

[1]. Fridkin M, et al. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol. 1989;24(1):1-40.

[2]. Wu M, et al. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimentalautoimmune encephalomyelitis. PLoS One. 2012;7(4):e34933.

Molecular Formula C25H48N8O10
Molecular Weight 620.70
PSA 289.78000
LogP 0.53410
Storage condition 2-8℃

~54%

72103-53-8 structure

72103-53-8

Literature: Dasgupta, S.; Chauhan, V. S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1138 - 1141

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72103-53-8 structure

72103-53-8

Literature: Dasgupta, S.; Chauhan, V. S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1138 - 1141