96027-74-6

96027-74-6 structure

Name: Desethyl Amiodarone Hydrochloride
Chemical Name: (2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone,hydrochloride
CAS Number: 96027-74-6
Molecular Formula: C₂₃H₂₆ClI₂NO₃
Molecular Weight: 653.719
Catalog: analytical chemistry Standard standard material
Create Date: 2018-12-27 13:27:26
Modify Date: 2024-01-08 19:41:23
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

Name	(2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone,hydrochloride
Synonyms	Desethylamiodarone hydrochloride desethylamiodarone (2-Butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone hydrochloride (1:1) Methanone, (2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-, hydrochloride (1:1) mono-N-desethylamiodarone hydrochloride Desethyl Amiodarone Hydrochloride Amiodarone Impurity 2

Description	Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Shayeganpour A, et al. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34(1):43-50. [2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

Boiling Point	630.3ºC at 760 mmHg
Melting Point	176-178ºC
Molecular Formula	C₂₃H₂₆ClI₂NO₃
Molecular Weight	653.719
Flash Point	335ºC
Exact Mass	652.969055
PSA	51.47000
LogP	7.39680
Storage condition	-20°C Freezer, Under Inert Atmosphere
Stability	Moisture Sensitive

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

4535-87-9

1951-26-4

~63%

96027-74-6

1096359-59-9

96027-74-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 22 p. 5920 - 5922

Precursor 3
4535-87-9 1951-26-4 1096359-59-9
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